[two] Aprobarbital was under no circumstances as greatly employed as a lot more typical barbiturate derivatives for instance phenobarbital which is now hardly ever prescribed as it's been replaced by newer medications with an improved safety margin.
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Barbiturates seem to boost the metabolism of exogenous corticosteroids likely in the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy might demand dosage adjustments if barbiturates are added to or withdrawn from their dosage program.
Routine maintenance of an adequate airway, with assisted respiration and oxygen administration as needed.
Signs or symptoms of barbiturate dependence are just like People of Persistent alcoholism. If a person seems to generally be intoxicated with alcohol to some diploma that is radically disproportionate to the quantity of alcohol in their blood using barbiturates really should be suspected. The lethal dose of a barbiturate is way considerably less if Alcoholic beverages can be ingested.
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Sodium valproate and valproic acid appear to lower barbiturate metabolism; thus, barbiturate blood concentrations really should be monitored and suitable dosage changes produced as indicated.
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While not suggested as a regime process, hemodialysis could be used in significant barbiturate intoxications or When the individual is anuric or in shock.
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